Figure 2: Down-Regulation of miR-24 in Response to Insulin Infusion in Human Plasma

Human plasma insulin (A), glucose (B), and miR-24 level (C) response to insulin infusion, normalized to spiked-in cel-miR-238. (D) Correlation of plasma miR-24 levels with insulin levels in T1DM patients. (E) Comparison of human plasma miR-24 levels in type 1 diabetes mellitus (T1DM) (n = 13) and type 2 diabetes mellitus (T2DM) (n = 27), normalized to spiked-in cel-miR-238; analysis of covariance was conducted while adjusting for age and sex. (F) Comparison of human plasma miR-24 levels in healthy subjects (HC) (n = 10) and T2DM without insulin therapy (n = 13) or with insulin therapy (n = 13), normalized to spiked-in cel-miR-238; analysis of covariance was conducted while adjusting for age and sex.

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