Figure 1: The Structure of BAG3 and its Protein-Binding Domains

The consensus protein-binding domains in B-cell lymphoma 2 (Bcl-2)–associated anthanogene (BAG3) (WW, IPV, PXXP, and BAG) and the putative signaling pathways that are regulated in cancer cells through each binding domain are shown. Numbers are amino acids. αB-crystallin = small heat shock protein B5 (HSPB5); CASA = chaperone-assisted selective autophagy; Hsc70/Hsp70 = constitutively expressed and the inducible heat shock protein 70; Hsp = heat shock protein; PLC-γ = phospholipase C-gamma; SH3 = SRC homology 3 domain.

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