Figure 1: The Cardiovascular Applications and Characteristics of iPSC-Derived Cardiomyocytes

(A) Immunostain of induced pluripotent stem cell (iPSC)-derived cardiomyocytes in cell culture demonstrate striated pattern of cardiac troponin T, α-actinin, connexin 43, and deoxyribonucleic acid (DNA). (B) Calcium metabolism and atomic force microscopy demonstrate live-cell calcium imaging of the contractile iPSC–derived cardiomyocytes, exhibiting regular and synchronous Ca2+ transients (left) with each contractile activity (right). (C) Histogram of atomic force microscopy evaluates the force exerted by each contraction of a representative iPSC-derived cardiomyocytes. The maximal contractile force measured for 4 representative beating cells was comparable to that of native cardiomyocytes (150 to ∼550 pN).