Figure 1: Summary of Experimental Protocols

Study I, protocol for inhibition of connective tissue growth factor (CTGF) during post—myocardial infarction (MI) cardiac repair (treatment initiation on day 3, treatment completion on day 7). Study II, protocol for CTGF inhibition during post-MI cardiac remodeling (treatment initiation on day 7, treatment completion at the end of week 7). Study III, protocol for CTGF inhibition during and/or after acute ischemia (treatment 24 and 1 h before ischemia or only at reperfusion). IgG = immunoglobulin-G; LAD = left anterior descending; mAb = monoclonal antibody.