Figure 1: Study Design of the Randomized Placebo Controlled Study

All subjects undergo MI reperfusion and after 4 weeks of recovery CMR is performed to establish baseline. After CMR scan 1, one-half the group is randomly chosen to be injected with CDCEXO and the other one-half with a placebo. Both groups undergo a second CMR scan after 4 weeks post-injection. CDCEXO = exosomes from cardiosphere-derived cells, CMR = cardiac magnetic resonance; MI = myocardial infarction.