Figure 1: Sex- and Age- and Multi-Adjusted* Association Between Serum PCSK9 Concentrations (Expressed as a Restricted Cubic Spline) and Risk of Incident MI (ORs; 95% CI)

(A) Sex- and age-adjusted; (B) multi-adjusted. *Adjusted for age, sex, diabetes mellitus, LDL-C, BMI, smoking, systolic blood pressure, diastolic blood pressure, triglycerides, HDL-C, log-transformed creatinine, and log-transformed C-reactive protein. †ORs with 95% CIs are displayed at the 2.5, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 and 97.5 percentiles of PCSK9, based on the quantile distribution among controls and using the 5th percentile as the reference level. BMI = body mass index; CI = confidence interval; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; MI = myocardial infarction; OR = odds ratio; PCSK9 = proprotein convertase subtilisin-kexin type 9.