Figure 1: Schematic Representation of the Therapeutic Target of the Mitochondrial Membrane Permeability Inhibitors

Ischemia and reperfusion lead to Ca++ overload and reactive oxygen species (ROS) formation leading to opening of the mitochondrial permeability transition pore (mPTP), cytochrome C (Cyt C) release into the cytoplasm, caspase-3 activation, and cell death. Cyclosporine, MTP-131, and TRO40303 inhibit mitochondrial membrane permeability and prevent cell death. mPTP = mitochondrial permeability transition pore.

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