Figure 1: S16D-Hsp20 Transgenic Mice Exhibit Reduced Survival, Left Ventricular Remodeling, and Dysfunction

(A) Kaplan-Meier survival curve of S16D and WT control mice. Longitudinal echocardiographic assessment of S16D and WT mice at 2, 4, and 6 months of age: (B) LVEDV; (C) LVESV; and (D) EF. Gravimetric analysis of S16D and WT control mice at 2, 4, and 6 months of age. Ratios of (E) heart weight/body weight and (F) lung weight/body weight in S16D and WT control mice. Values are mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001 versus WT. The number of samples (n) per group is indicated on the bar graphs. EF = ejection fraction; LVEDV = left ventricular end diastolic volume; LVESV = left ventricular end systolic volume; S16D = phosphorylated Hsp20; WT = wild type.

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