Figure 1: Possible Mechanism of GLP-1-Mediated Cardioprotection: A Complex Web

GLP-1 cardioprotection appears to be mediated through a number of complex and interrelated cellular mechanisms. Figure 1 shows a number of proposed actions through which GLP-1 may exert its protective effect. Detailed physiological and biochemical studies are needed to tease out the relevant contributions of different actions and, indeed, determine whether some of these are “red-herrings.”