Figure 1: Parallels Between Zebrafish and Human Physiology and Pharmacology

2019-06-11T07:03:24Z (GMT) by Aaron Kithcart Calum A. MacRae
(A) Ventricular action potential (AP) durations in wild-type (wt) and breakdance heterozygotes (+/−) and homozygotes (−/−) at 6 days post-fertilization. *p < 0.05. (B) Typical ventricular APs are displayed for wt, breakdance heterozygote, and homozygote embryos. The heterozygote AP is subtly prolonged, while the homozygote shows marked AP prolongation. Vertical calibration bar denotes 20% ΔF/F0, and the horizontal bar denotes 100 ms. (C) (Top) Simultaneous atrial and ventricular voltage recordings from breakdance (−/−) heart showing the mechanism of 2:1 atrioventricular block: APs are so prolonged in the ventricle that alternate atrial impulses encroach on the refractory plateau of the previous ventricular repolarization. (Bottom) Early afterdepolarizations (arrows) in breakdance (−/−) embryos during ventricular pacing; the pacing train is shown below the AP recording. (D) Heterozygote breakdance embryos display increased sensitivity to 10 nmol/l dofetilide. ∗p < 0.05.