Figure 1: Genome and Phenome-Wide Associations of Coronary Atherosclerosis, a Fundamental Mechanism Driving Several Cardiovascular Diseases

(A) Circos plot representing genome-wide associations of coronary atherosclerosis with each section representing human chromosomes. Phenome-wide associations of cardiovascular disease variants across other disease categories are represented in different colors. (B) rs11209026, a coding variant (c.G>A: R381Q) localized on interleukin-23 receptor (IL-23R); and (C) rs3184504 coding variant (c.784T>C: W262R) localized to PH domain of the SH2B3 protein.