Figure 1: Diabetes Exacerbates Myocardial Infarction and Ischemia/Reperfusion Injury

(A) Comparison of fasting blood glucose levels in diabetic mouse models (n = 10 to 12). (B) Enzyme-linked immunosorbent assay analysis of fasting plasma insulin levels in diabetic mouse models (n = 8 to 10). (C to E) Comparison of infarct size between wild-type (WT) and db/db (leptin receptor knockout) mice subjected to ischemia for 20 min and reperfusion for 3 h. (F) Survival curve (log-rank [Mantel-Cox] test) of WT, streptozotocin (STZ)-induced type 1 diabetes (with or without insulin therapy), and db/db (with or without insulin therapy) subjected to 20 min ligation of left anterior descending coronary artery (LAD) followed by ischemia/reperfusion (I/R) for 4 weeks.

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