Figure 1: Cardiac Lymphatic Drainage of an Adult Mouse Heart

(A) Cross-section of a heart demonstrates the direction of cardiac lymph drainage from endocardium, myocardium to epicardium (flow indicated by arrows). (B) Two major collecting vessels (green) on the epicardium then assist to drain lymph, originally derived from the endocardium, from apex to base: one collecting vessel (left) runs along the left conal vein upward to the pulmonary trunk and mediastinum; the other vessel (right) runs along the left cardiac vein and passes the coronary sinus and left atrium upward to the mediastinum.