Figure 1: Body Weight, LV Mass, and Cardiac Function in Empagliflozin-Treated

Body weight (n = 16 to 19/group) (A) and ventricular mass measured after sacrifice (n = 12 to 13/group) (B) are shown. Cardiac work presented in J ∙ min−1 ∙ gram dry weight−1 (C) and cardiac output in ml ∙ min−1 (D) (n = 19 to 20/group) determined by isolated working heart perfusion are shown. Data are presented as mean ± SEM. Data were analyzed by 1-way analysis of variance (ANOVA) followed by least significant difference (LSD) post hoc test. Cardiac work and cardiac output were analyzed by repeated 1-way ANOVA followed by LSD post hoc test. *p < 0.05 was considered as a significantly different comparison with C57BL/6J + Vehicle. †p < 0.05 was considered as a significantly different comparison with db/db + Vehicle.

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