Figure 1: Assessment of Heart Rate and SAN Function in Wild-Type and NPR-C

(A) Representative ECG recordings obtained during intracardiac programmed stimulation in anesthetized wild-type and NPR-C−/− mice treated with saline or Ang II to measure SNRT. (B) Summary of heart rate in wild-type and NPR-C−/− mice treated with saline or Ang II. (C) Summary of cSNRT in wild-type and NPR-C−/− mice treated with saline or Ang II. *p < 0.001 versus saline; +p < 0.001 versus wild type by 2-way analysis of variance with Tukey post hoc test; n = 28 mice for wild-type/saline treatment, 29 mice for wild-type/Ang II treatment, 19 mice for NPR-C−/−/saline treatment, and 19 mice for NPR-C−/−/Ang II treatment. Ang II = angiotensin II; cSNRT = corrected SNRT; ECG = electrocardiography; NPR-C= natriuretic peptide receptor C; SAN = sinoatrial node; SNRT = sinoatrial node recovery time.