Figure 10: Induced PP2Ce Expression Promotes Cardiomyocyte Death in Response to I/R Injury

(A) Representative TTC staining cross section images from 1 PP2Ce TG and 1 control heart following 15 min of ischemia and 120 min of reperfusion (I/R). (B) Infarct sizes of control (n = 5) and PP2Ce TG (n = 6) hearts as measured from (A). (C) Apoptotic index measured by TUNEL staining in control (n = 4) and PP2Ce TG (n = 4) hearts. (D) Representative immunoblot for level of activated caspase 9 in control (n = 10) and PP2Ce TG (n = 8) hearts following the same I/R protocol. (E) Quantification of level of cleaved caspase 9 signal from immunoblots. *p < 0.05 between control and PP2Ce TG groups. **p < 0.01 between control and PP2Ce TG groups. Abbreviations as in Figures 2, 3, and 4.

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