Figure 2: Expression of Plaque-Associated Biomolecules in Unobstructed Coronary Arteries, Across Obstructive/Narrowed Lesions and After Angioplasty of Coronary Atherosclerotic Plaques
Nick E.J. West
Joseph P. Corrigan
Richard H.G. Owen
Stephen P. Hoole
Adam J. Brown
Stephen Blatcher
Andrew C. Newby
10.25407/JACBTS.8255498.v1
https://multimedia.onlinejacc.org/articles/Figure_2_Expression_of_Plaque-Associated_Biomolecules_in_Unobstructed_Coronary_Arteries_Across_Obstructive_Narrowed_Lesions_and_After_Angioplasty_of_Coronary_Atherosclerotic_Plaques/8255498
<b>(A)</b> A summary is shown of biomarker gradients measured in blood sampled across the proximal to distal ports of the LBS system. <b>(B)</b> In 1 study, samples were taken from unobstructed vessels (green vessel). <b>(C)</b> In a separate study, samples were taken from narrowed or obstructive atherosclerotic plaques, where possible, before balloon dilation (yellow vessel) and in the same and other vessels <b>(D)</b> (red vessel) after balloon dilation. Data are volcano plots, with each identified biomolecular gradient represented by a single point, with effect size (median percentage of change of biomolecule concentration over a distance of 6 cm [PP-DP] within coronary artery) plotted on the x-axis and statistical significance (−log10[p value]) on the y-axis. The <b>dashed horizontal line on each graph</b> represents corrected threshold for significance of each gradient (p[FDR] <0.05); the vertical dashed line represents zero gradient. p(FDR) = false discovery rate p value; NPX = normalized protein expression.
2019-06-11 07:08:56
biomolecule release
coronary atherosclerosis
inflammation
vulnerable plaque