Figure 2: Aortic Root Lesion Formation in Renal Impairment Is Enhanced by IL-17 Receptor A
NordlohneJohannes
HelmkeAlexandra
GeShuwang
RongSong
ChenRongjun
WaismanAri
HallerHermann
von VietinghoffSibylle
2019
<i>LDLr</i><sup><i>–/–</i></sup> and <i>Il17ra</i><sup><i>–/–</i></sup><i>LDLr</i><sup><i>–/–</i></sup> male mice were kept on a high-fat diet for 10 weeks after RI or ctrl surgery. <b>(A and B)</b> Aortic root lesions were assessed by histology (typical examples, bar indicates 500 μm, and statistical analysis of n = 5 to 6 per group <i>LDLr</i><sup><i>–/–</i></sup> mice and n = 4 to 5 <i>Il17ra</i><sup><i>–/–</i></sup><i>LDLr</i><sup><i>–/–</i></sup> mice from 3 independent experiments, 2-way ANOVA, significant effects of treatment group [p < 0.0001] and distance [p < 0.0001], no significant interaction for <b>A or B</b>). <b>(C)</b> Aortic roots were stained for CD11b <b>(green)</b> and CD11c <b>(red)</b> with nuclear counterstain (4',6-diamidino-2-phenylindole [DAPI], <b>blue</b>) (typical examples, 10× and 20× original magnification, <b>bars</b> indicate 500 and 250 μm, respectively). Abbreviations as in Figure 1.