Manning, Janet R.
Chelvarajan, Lakshman
Levitan, Bryana M.
Withers, Catherine N.
Nagareddy, Prabhakara R.
M. Haggerty, Christopher
K. Fornwalt, Brandon
Gao, Erhe
Tripathi, Himi
Abdel-Latif, Ahmed
Andres, Douglas A.
Satin, Jonathan
Figure 1: Mortality Is Reduced in Rad
<b>(A)</b> Survival curve of wild-type (WT) and Rad<sup>−/−</sup> shows significantly fewer spontaneous deaths in Rad<sup>−/−</sup> mice. *p < 0.05, WT versus Rad<sup>−/−</sup> mice. N = 63 WT myocardial infarction (MI), 75 Rad<sup>−/−</sup> MI, 25 WT sham, and 33 Rad<sup>−/−</sup> sham mice at risk at day 0. After 50 days, there were 58 WT MI mice at risk, and at 100 days, there were 57 WT MI mice at risk; all other counts remained the same as at 0 days. <b>(B)</b> Long-axis echocardiographic images taken during diastole. <b>Arrows</b> denote boundaries of scar region. <b>(C)</b> Representative hearts fixed after 5 weeks of ischemia. <b>Arrow</b> indicates suture occluding the left anterior descending coronary artery. <b>(D)</b> Representative sections of post-MI hearts stained for Masson’s trichrome. <b>Arrows</b> mark interstitial fibrosis. <b>(E)</b> Measurements of scar length in post-MI WT and Rad<sup>−/−</sup> hearts as a percentage of the left ventricular midline. <b>(F)</b> Interstitial fibrosis score in noninfarcted myocardium (1 = little to no fibrosis, 5 = severe fibrosis). N = 5 WT and 11 Rad<sup>−/−</sup> mice.
calcium channel;cardioprotection;inflammation;myocardial infarction
2019-06-11
https://multimedia.onlinejacc.org/articles/Figure_1_Mortality_Is_Reduced_in_Rad/8254997

10.25407/JACBTS.8254997.v1