Figure 1: Mortality Is Reduced in Rad
Janet R. Manning
Lakshman Chelvarajan
Bryana M. Levitan
Catherine N. Withers
Prabhakara R. Nagareddy
Christopher M. Haggerty
Brandon K. Fornwalt
Erhe Gao
Himi Tripathi
Ahmed Abdel-Latif
Douglas A. Andres
Jonathan Satin
10.25407/JACBTS.8254997.v1
https://multimedia.onlinejacc.org/articles/Figure_1_Mortality_Is_Reduced_in_Rad/8254997
<b>(A)</b> Survival curve of wild-type (WT) and Rad<sup>−/−</sup> shows significantly fewer spontaneous deaths in Rad<sup>−/−</sup> mice. *p < 0.05, WT versus Rad<sup>−/−</sup> mice. N = 63 WT myocardial infarction (MI), 75 Rad<sup>−/−</sup> MI, 25 WT sham, and 33 Rad<sup>−/−</sup> sham mice at risk at day 0. After 50 days, there were 58 WT MI mice at risk, and at 100 days, there were 57 WT MI mice at risk; all other counts remained the same as at 0 days. <b>(B)</b> Long-axis echocardiographic images taken during diastole. <b>Arrows</b> denote boundaries of scar region. <b>(C)</b> Representative hearts fixed after 5 weeks of ischemia. <b>Arrow</b> indicates suture occluding the left anterior descending coronary artery. <b>(D)</b> Representative sections of post-MI hearts stained for Masson’s trichrome. <b>Arrows</b> mark interstitial fibrosis. <b>(E)</b> Measurements of scar length in post-MI WT and Rad<sup>−/−</sup> hearts as a percentage of the left ventricular midline. <b>(F)</b> Interstitial fibrosis score in noninfarcted myocardium (1 = little to no fibrosis, 5 = severe fibrosis). N = 5 WT and 11 Rad<sup>−/−</sup> mice.
2019-06-11 07:06:31
calcium channel
cardioprotection
inflammation
myocardial infarction