Figure 2: Intact ECM Scaffold Attenuates Maladaptive Structural Remodeling
MewhortHolly E.M.
SvystonyukDaniyil A.
TurnbullJeannine D.
TengGuoqi
BelkeDarrell D.
GuzzardiDavid G.
S. ParkDaniel
KangSean
D. HollenbergMorley
FedakPaul W.M.
2019
<b>(A)</b> Representative images of LV divided long axis depicting relative LV volumes and geometry. <b>(B)</b> Representative images of the treated infarcted anterior LV wall (<b>dashed line</b> indicates the endocardial and epicardial borders of the LV wall) depicting anterior wall thickness and ECM scaffold. <b>(C)</b> LVEDV measured by PV loop analysis in sham-treated (n = 16) and intact (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals 14 weeks post-MI (1-way ANOVA). Infarcted LV anterior wall thickness measured by echocardiography in sham-treated (n = 16) and intact (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals. <b>(D)</b> Significant differences were observed for effects of time (p = 0.0012), group (p = 0.034), and interaction (group × time, p = 0.034) (repeated measures 2-way ANOVA). <b>(E)</b> LV stiffness indicated by end-diastolic pressure-volume relationship (EDPVR) measured by PV loop analysis in sham-treated (n = 16) and intact- (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals 14 weeks post-MI (1-way ANOVA). Abbreviations as in Figure 1.