%0 DATA
%A Holly E.M., Mewhort
%A Daniyil A., Svystonyuk
%A Jeannine D., Turnbull
%A Guoqi, Teng
%A Darrell D., Belke
%A David G., Guzzardi
%A Daniel, S. Park
%A Sean, Kang
%A Morley, D. Hollenberg
%A Paul W.M., Fedak
%D 2019
%T Figure 2: Intact ECM Scaffold Attenuates Maladaptive Structural Remodeling
%U https://multimedia.onlinejacc.org/articles/Figure_2_Intact_ECM_Scaffold_Attenuates_Maladaptive_Structural_Remodeling/8254742
%R 10.25407/JACBTS.8254742.v1
%2 https://multimedia.onlinejacc.org/ndownloader/files/15430877
%K extracellular matrix
%K regeneration
%K vasculogenesis
%X **(A)** Representative images of LV divided long axis depicting relative LV volumes and geometry. **(B)** Representative images of the treated infarcted anterior LV wall (**dashed line** indicates the endocardial and epicardial borders of the LV wall) depicting anterior wall thickness and ECM scaffold. **(C)** LVEDV measured by PV loop analysis in sham-treated (n = 16) and intact (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals 14 weeks post-MI (1-way ANOVA). Infarcted LV anterior wall thickness measured by echocardiography in sham-treated (n = 16) and intact (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals. **(D)** Significant differences were observed for effects of time (p = 0.0012), group (p = 0.034), and interaction (group × time, p = 0.034) (repeated measures 2-way ANOVA). **(E)** LV stiffness indicated by end-diastolic pressure-volume relationship (EDPVR) measured by PV loop analysis in sham-treated (n = 16) and intact- (n = 16) and glutaraldehyde-inactivated (n = 16) ECM scaffold–treated animals 14 weeks post-MI (1-way ANOVA). Abbreviations as in Figure 1.