Figure 4: Renal Denervation Reduced the Pulmonary Vascular Remodeling
da Silva Gonçalves BosDenielli
HappéChris
SchalijIngrid
PijackaWioletta
PatonJulian F.R.
GuignabertChristophe
TuLy
ThuilletRaphaël
BogaardHarm-Jan
C. van RossumAlbert
Vonk-NoordegraafAnton
de ManFrances S.
HandokoM. Louis
2019
Representative examples of pulmonary arterioles (Elastica van Gieson) (scale bar, 20 μm). <b>(A)</b> Examples from the MCT model. <b>(B)</b> Examples from the SuHx model. RD reduced significantly the wall thickness of the pulmonary arterioles, as observed by a reduction in both the media (<b>C:</b> MCT; <b>D:</b> SuHx), and intima layers (<b>E:</b> SuHx). In addition, RD increased significantly the percentage of open vessels and reduced the number of full obliterated vessels in both PH-models (<b>F:</b> MCT; <b>G:</b> SuHx). <b>A:</b> Control: n = 5, MCT-sham: n = 9, and MCT-RD: n = 9; <b>B:</b> Control: n = 6, SuHx-sham: n = 10, and SuHx-RD: n = 10. Data are presented as mean ± SEM. Multilevel analysis to correct for non-independence of successive measurements per animal. FO = fully obliterated vessels; PO = partially obliterated vessels; other abbreviations as in Figure 1.