%0 DATA
%A Mei, Hua Gao
%A N., Chin Lai
%A Dimosthenis, Giamouridis
%A Young Chul, Kim
%A Zhen, Tan
%A Tracy, Guo
%A Wolfgang, H. Dillmann
%A Jorge, Suarez
%A H., Kirk Hammond
%D 2019
%T Figure 3: C1C2 Expression Prevents Deleterious Effects of Continuous Isoproterenol Infusion on LV Function
%U https://multimedia.onlinejacc.org/articles/figure/Figure_3_C1C2_Expression_Prevents_Deleterious_Effects_of_Continuous_Isoproterenol_Infusion_on_LV_Function/8254025
%R 10.25407/JACBTS.8254025.v1
%2 https://multimedia.onlinejacc.org/ndownloader/files/15430145
%K cardiomyopathy
%K catecholamine
%K gene therapy
%K heart failure
%X **(A**, **B)** In Con, 7 days of continuous Iso infusion tended to reduce LV peak +dP/dt **(A)** and LV peak −dP/dt **(B)**. In contrast, in C1C2 mice, 7 days of Iso infusion increased LV peak +dP/dt (p = 0.026) **(A)** and peak −dP/dt (p = 0.006) **(B)**. No between-group differences were seen in pre-Iso LV +dP/dt (p = 0.22) or LV −dP/dt (p = 0.27). **(C)** Similarly, continuous Iso infusion was associated with reduced LV developed pressure in Con mice (p = 0.012) but with increased LV developed pressure in C1C2 mice (p = 0.016). **(D)** Heart rate showed no group differences within or between groups. **(E)** Histological analysis of fixed transmural LV samples stained with Picro Sirius red showed increased LV fibrosis after 7 days (7d) of continuous Iso infusion in Con mice only (p = 0.02), but a between-group difference in fibrosis at 7 days was not seen. **Bars** = mean values; SE = error bars; **values in bars** = numbers of mice. Two-way ANOVA showed significant interaction of C1C2 on LV peak +dP/dt (p = 0.012), LV peak −dP/dt (p = 0.0009), and LVP (p = 0.0003); numbers above bars indicate p values from within-group post hoc comparisons (Student *t-*test, unpaired, 2-tailed, Bonferroni correction). Con = transgene negative mice; other abbreviations as in Figures 1 and 2.